South Carolina Multistate Pharmacy Jurisprudence Examination (MPJE) Practice Exam

Which drug is classified as a Schedule III (C3) substance?

1. Tramadol

2. Codeine

3. Hydromorphone

4. Oxycodone

The correct answer is: Codeine

The classification of substances into schedules is based on their potential for abuse, accepted medical use, and the degree of dependence they may cause. Schedule III substances have a moderate potential for abuse and may lead to low or moderate physical dependence or high psychological dependence. Codeine, when combined with a non-narcotic analgesic like acetaminophen or aspirin, is classified as a Schedule III substance. This means that certain formulations containing codeine are recognized for their legitimate medical use while also acknowledging the potential for abuse. Its classification reflects the balance between its therapeutic benefits and risks associated with its misuse. In contrast, medications like tramadol, hydromorphone, and oxycodone fall into different schedules due to their higher potential for abuse and dependency. For instance, tramadol is classified as a Schedule IV substance, while hydromorphone and oxycodone are classified as Schedule II substances, indicating a higher risk compared to codeine-containing products. Understanding these classifications helps healthcare professionals ensure proper prescribing and dispensing while minimizing the risk of substance misuse.