Which of the following is a characteristic of C4 medications?

C4 medications, classified as Schedule IV controlled substances, are characterized by a low potential for abuse relative to medications categorized as Schedule III (C3). This classification indicates that while C4 substances can still pose some risk of addiction or dependence, they are generally considered less likely to lead to significant physical or psychological dependence compared to C3 substances.

For additional context, the other options do not align with the characteristics of C4 medications. C4 substances do not have a high potential for abuse; that distinction is reserved for schedules I and II. They do indeed require a prescription but cannot be sold over-the-counter, as they are still restricted in their use and distribution. Lastly, there are specific regulations related to the refilling of prescriptions for C4 medications; they are subject to limits on refills, unlike the implication that there are no restrictions on refills. Understanding these distinctions is critical for comprehending the scheduling and regulation of controlled substances.