South Carolina Multistate Pharmacy Jurisprudence Examination (MPJE) Practice Exam

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Which of the following medications is classified as a C4 controlled substance?

  1. Buprenorphine

  2. Phenobarbital

  3. Cannabidiol

  4. Codeine

The correct answer is: Phenobarbital

Phenobarbital is classified as a C4 controlled substance due to its potential for abuse and dependence. It is a barbiturate that acts as a central nervous system depressant and is used primarily to treat seizures and anxiety. The scheduling of phenobarbital is based on its risk of leading to physical and psychological dependence, placing it in the lower tier of controlled substances compared to those classified as C1, C2, or C3. The other options differ in their classifications: buprenorphine, while a useful medication for opioid dependence and pain management, is classified as a C3 controlled substance. Cannabidiol, typically derived from hemp and not associated with abuse potential, is not classified as a controlled substance. Codeine, depending on its formulation and concentration, may be classified as a C2 or C3 but is not categorized as a C4 controlled substance. This understanding of scheduling is essential for ensuring compliance with federal and state regulations regarding prescribing and dispensing controlled substances.