South Carolina Multistate Pharmacy Jurisprudence Examination (MPJE) Practice Exam

Which program is associated with the restricted distribution of isoretinoin?

1. STEPS

2. iPledge

3. Isotretinoin Registry

4. RAWP

The correct answer is: iPledge

The program associated with the restricted distribution of isoretinoin is iPledge. This program was developed in response to the serious risks associated with isoretinoin, including severe birth defects if taken during pregnancy. iPledge is a risk management program that mandates that healthcare professionals, patients, and pharmacies adhere to strict protocols to mitigate pregnancy risks and ensure safe use of the medication. Under the iPledge program, patients are required to sign a consent form that informs them about the drug's potential risks and the requirements they must follow, including regular pregnancy testing and the use of effective contraception during treatment. Prescribers must also be registered with the program and follow specific guidelines when prescribing isoretinoin. The pharmacy dispensing isoretinoin must verify that the patient is enrolled in iPledge, ensuring compliance with the safety measures outlined. The other options refer to similar programs or registries but are not specifically linked to the restricted distribution of isoretinoin. For example, the STEPS program pertains to the distribution of thalidomide, while the Isotretinoin Registry serves a different purpose related to tracking outcomes. RAWP may refer to other pharmaceutical practices but does not apply in this context. Therefore, iPledge's